ACCELERATING PROMISING ONCOLOGY THERAPEUTICS INTO THE CLINIC THROUGH COLLABORATIVE DRUG DEVELOPMENT
USC Norris Comprehensive Cancer Center (USC Norris) is pleased to launch the Rosalie and Harold Rae Brown Center for Cancer Drug Development (CCDD) with a generous gift from the Rosalie and Harold Rae Brown Foundation. The CCDD employs an integrated academic-industry focused management model to engage investigators from different disciplines, collapse gaps in expertise, resources, and funding, and ensure that programs have a high likelihood of progressing to late Pre-Clinical stage development and submission of an Investigational New Drug (IND) application. Initial projects will be sharply focused on cancers that disproportionately affect members of the community for whom there are dramatic ethnic and racial disparities, such as breast cancer, prostate cancer and colorectal cancer, and blood cancers.
“This gift will have an immediate impact by transforming USC Norris discoveries of the underlying causes of cancer and disease progression into new treatments and clinical trials for our patients.”
The USC Norris CCDD drug development process is uniquely structured in partnership with faculty to accelerate a rigorous review of projects. This process will be managed by the MESH Academy Business Development and Industry Relations team to ensure transparency, establish a central point of contact, and reduce redundancies and missed opportunities.
Faculty are invited to complete the USC Norris CCDD in-take form and return this form to the MESH Business Development and Industry Relations (BDIR) team. The in-take form will also be made available on the KSOM intranet, MESH website, or can be requested directly from the MESH team.
This form is the first step in the CCDD review process that is focused on scientific rationale and unmet need. The MESH BDIR team will review the in-take forms and triage according to the specific criteria and responses provided by the faculty. This is a collaborative approach and faculty who have submitted projects can expect frequent interactions with MESH BDIR throughout the review process.
Upon review, faculty will be notified whether their submission enters the second step: Deep Dive review (commercial viability and IP analysis). MESH BDIR will research information on the competitive landscape for a submitted project and connect with the USC Stevens Center for Innovation to obtain information on intellectual property matters as needed. This information is incorporated with the intake form and each project is presented to the CCDD Directors and the USC Norris Executive Committee for review. CCDD Directors will then present this information to an External Advisory Committee (EAC) for feedback, which will enable the prioritization of targets.
The list of prioritized targets and the feedback from the EAC will be presented to the USC Norris Director who will decide whether to advance the project to the next stage, with input from the USC Norris Executive Committee.
For targets that are advanced, faculty will work collaboratively with CCDD Directors to develop a plan, including development of milestones, budget, timeline, additional resources needed, and partnering strategy. For targets that do not advance, faculty will receive feedback and have an opportunity to resubmit.
Approved projects typically fall into one of these categories:
The MESH BDIR team will collaborate with the faculty/project team and with potential prospective external collaborators to formulate a partnering strategy that is mutually beneficial. The focus of the partnering zone is to:
For general questions or interests in partnering with the CCDD, please contact Vasiliki Anest, Business Director.
To learn more about giving to USC Norris, please contact Robert Weiner, Assistant Vice President of Development, at Robert.Weiner@med.usc.edu.