USC Norris created the Population Research Core (PRC) in July 2019 to address the need for a state-of-the-art shared resource to provide consultation, access, and support for leveraging population-based data resources. The mission of the PRC is to maximize the impact of USC Norris’ catchment-relevant research by providing members with consultation and coordinated access to unique local and national population-based data resources and assessment tools. The PRC provides this data to the USC Norris Data Science Core for integration with clinical and or other data and subsequent analysis. In certain specialized areas, such as geospatial analysis, the PRC also provides analytic support. In its first year of operation, the PRC supported 34 funded projects in the Cancer Control Research Program, Cancer Epidemiology Research Program, and Translational and Clinical Sciences Program (five of which contributed to new externally funded projects). The PRC also supports the Office of Community Outreach and Engagement (COE) by providing population data from multiple sources (incidence, mortality, risk factors) as well as geospatial data intervention targeting.