The USC Norris Comprehensive Cancer Center Microarray Core is located at Childrens Hospital Los Angeles, the pediatric facility of the Center. Services available include gene expression profiling with a variety of arrays, including human, mouse and rat; mutation analyses (p53); HIV, yeast, and bacterial genome analyses; and SNP analyses. RNA or DNA will be extracted, purified, labeled, and in the case of expression chips, converted into double stranded cDNA, and thence to cRNA, labeled and fragmented. We hybridize these samples to the arrays specified by the investigator, scan them, and determine the quality of the hybridization. The data will then be interpreted by our computational biologist, who will confirm the findings with the director and pass these results to the investigator or customer on a CD. Additional analyses will be available on a matching computer workstation at USC Norris Comprehensive Cancer Center.
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