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About USC Norris
FAQ - Trials
Contact Us - Trials
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If you are a patient, please contact
The Doctors of USC
Collaborative Advanced Stage Tissue Lung Cancer (CASTLE) Network.
Open to Accrual
Defintions of terms and FAQ about clinical trials.
Barbara Gitlitz, M.D.
Other Trial Staff:
Charlean Ketchens, R.N., Lagrimas Ilagan, D.M., Gina Tse, R.N., Eduardo Mejia, D.M.
to see study documents.
You may participate in this study if:
M1A or B NSCLC or any stage SCLC with any number of prior therapies
Planned systemic therapy
At least 18 years of age
Measurable or evaluable disease
ECOG performance status of 0-2
Expected survival at least 3 months
Tumor specimens: [a] First Priority: availability of a minimum of a 1 X 10 mm core fresh frozen tumor from clinically indicated interventional procedures, with no systemic anti-cancer therapy or radiation to the biopsy site between collection of the biopsy and entry into the study; OR [b] Second Priority: availability of paraffin-embedded tumor at least 5 X 5 mm cross-sectional tumor area, with no systemic anti-cancer therapy or radiation to the biopsy site between collection of the biopsy and entry into the study; the collection of the paraffin-embedded tissues may have taken place up to 12 months prior to enrollment in CASTLE.
Willingness to undergo all study collection procedures and sample analyses
Provision of written informed consent for biospecimen storage, broad genetic and proteomic analysis of tumor and normal tissues, without restrictions, AND correlation with outcome data.
You may not participate in this study if:
Other co-existing malignancies, except for basal cell carcinoma or cervical cancer in-situ
Compromise of patient diagnosis or staging if tissue is harvested for research
For further information on a study, please contact the Clinical Investigation Support Office at (323) 865-0451, or
To schedule a consultation with the hospital, please call our New Patient Referrals Office at (323) 865-3111.