| | Requirement |
| 1 | Histologically confirmed cancer that will be treated with 5-FU-based chemotherapy. |
| 2 | At least 18 years of age. |
| 3 | Prior chemotherapy is allowed. No prior 5-FU therapy is allowed, except when patients are treated with novel fluoropyrimidine compounds (xeloda or alimpta). |
| 4 | Must allow the use of their fresh frozen or paraffin-embedded tumor tissue that has been previously collected. Tumor tissue should be collected prior to the start of fluoropyrimidine therapy. |
| 5 | Signed informed consent. |
| 1 | Limited amount of tumor tissue available for diagnostic purposes. The pathologists, Drs. Sherrod and Naritoku will make the decision whether there is sufficient material for this study. |
