University of Southern California
USC Norris Comprehensive Cancer Center

Genomic and Epigenomic Regulation

The Genomic and Epigenomic Regulation (GER) Program at USC Norris cultivates research collaborations between its members as well as with researchers from other USC Norris Research Programs and peer institutions. The overarching goal is to translate basic discoveries into new methods for cancer prevention, detection, prognosis, and treatment. The program has two specific aims: 1) characterize the genome, epigenome, and transcriptome of cancer cells and 2) characterize signaling pathways that regulate genome replication and integrity, epigenetics, and gene expression to identify critical genes and pathways as potential targets.

The program co-leaders, Michael Stallcup, PhD, and Woojin An, PhD, have complementary recognized expertise in steroid hormone signaling and gene regulation by transcription factors and their coregulators, as well as epigenomic and chromatin-based regulatory mechanisms of gene expression and cell growth. The program brings together 40 members from 17 departments and four schools at USC who have obtained two U01, one U19, two U54, and two P01 grants to drive fundamental discovery and translation. The program fosters member interactions and drives novel collaborations through its leadership in cancer-focused PhD training programs. The GER program has a unique impact on specific populations of our LA County catchment area, including high impact work in acute lymphoblastic leukemi (ALL), liver cancer, colorectal cancer, and prostate cancer.